Generalized Social Anxiety Disorder (SAD) is one of the most common anxiety conditions with impairment in social life. Cannabidiol (CBD), one major non-psychotomimetic compound of the* that is( sativa plant, indicates anxiolytic impacts both in people plus in pets. This study that is preliminary to compare the effects of a simulation public speaking test (SPST) on healthy control (HC) patients and treatment-naïve SAD patients who received a single dose of CBD or placebo. A total of 24 never-treated patients with SAD were allocated to receive either CBD (600 mg; n=12) or placebo (placebo; n=12) in a double-blind design that is randomized h and a half ahead of the test. The number that is same of (n=12) performed the SPST without receiving any medication. Each volunteer participated in only one experimental session in a procedure that is double-blind. Subjective reviews in the analogue that is visual Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST. The results were submitted to a repeated-measures analysis of variance. Pretreatment with CBD significantly reduced anxiety, cognitive discomfort and impairment within their message performance, and somewhat reduced alert within their anticipatory message. The placebo team offered greater anxiety, cognitive disability, disquiet, and levels that are alert compared with the control group as assessed with the VAMS. The SSPS-N scores evidenced significant increases during the testing of placebo group that was almost abolished in the* that is( team. No significant distinctions had been observed between CBD and HC in SSPS-N ratings or into the impairment that is cognitive discomfort, and alert factors of VAMS. The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a response that is similar the HC.
1Department of Neuroscience and Behavior, class of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil.